Overview

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
USERS' SCORE
Moderately Good
Based on 4 Reviews
7
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Folate
667 mcg DFE (400 mcg Folic Acid)
167%
Calcium (as Calcium Carbonate)
100 mg
8%

Top Medical Research Studies

We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.

The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.

Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
Read More
9.5
Weight loss resolves sleep apnea
We examined the effects of bariatric surgery on children aged 8 to 18 facing severe obesity. The study involved 22 children, half of whom had sleep apnea.

Remarkably, children with sleep apnea experienced a significant drop in BMI after surgery, leading to the resolution of their sleep difficulties.

Additionally, many reported improvements in school performance and overall quality of life. While there were a few postoperative complications, the surgeries were deemed safe, promoting the idea that similar interventions can benefit severely obese children.
Read More
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.

In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.

This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.

Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
Read More

Most Useful Reviews

9.5
Health benefits attained
Mumtaz is a wonderful product. The small grains lack smell or taste, making them easy to consume. Their benefits for the brain, heart, mood, and sleep are essential and effective for anyone caring about their health.
Read More
2.5
Caution advised
Be careful! I had sleep disturbances and read online that folic acid could help with morning migraines. I took one tablet daily for a month and later increased to two. Initially, there were positive effects - normalised sleep, improved mood, and reduced hair loss. However, after 2.5 months, I experienced serious side effects, including heavy periods due to increased estrogen levels. Consult a doctor before use.
Read More
8.8
Improved sleep quality
I ordered 21st Century folic acid, 400 μg, 250 tablets for the first time. The large packaging arrived undamaged. Based on reviews, the quality seems good. The small tablets are easy to swallow and have a neutral, slightly salty taste. After a few weeks, I noticed a return to normalcy in my nervous system, increased strength, improved sleep, and more energy.
Read More

Medical Researches

SCIENTIFIC SCORE
Moderately Effective
Based on 3 Researches
8.2
  • All Researches
9.5
Weight loss resolves sleep apnea
We examined the effects of bariatric surgery on children aged 8 to 18 facing severe obesity. The study involved 22 children, half of whom had sleep apnea.

Remarkably, children with sleep apnea experienced a significant drop in BMI after surgery, leading to the resolution of their sleep difficulties.

Additionally, many reported improvements in school performance and overall quality of life. While there were a few postoperative complications, the surgeries were deemed safe, promoting the idea that similar interventions can benefit severely obese children.
Read More
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.

In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.

This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.

Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.
Read More
We examined the connection between dietary components and the severity of obstructive sleep apnea (OSA) in a group of 303 adults from Cyprus.

The study indicated that higher energy intake increases OSA severity. However, we noticed that participants with higher folic acid intake tended to have less severe cases of OSA.

Thus, while diet impacts OSA severity, folic acid may offer a protective benefit that could be significant in managing this condition.
Read More

User Reviews

USERS' SCORE
Moderately Good
Based on 4 Reviews
7
  • All Reviews
  • Positive Reviews
  • Negative Reviews
9.5
Health benefits attained
Mumtaz is a wonderful product. The small grains lack smell or taste, making them easy to consume. Their benefits for the brain, heart, mood, and sleep are essential and effective for anyone caring about their health.
Read More
2.5
Caution advised
Be careful! I had sleep disturbances and read online that folic acid could help with morning migraines. I took one tablet daily for a month and later increased to two. Initially, there were positive effects - normalised sleep, improved mood, and reduced hair loss. However, after 2.5 months, I experienced serious side effects, including heavy periods due to increased estrogen levels. Consult a doctor before use.
Read More
8.8
Improved sleep quality
I ordered 21st Century folic acid, 400 μg, 250 tablets for the first time. The large packaging arrived undamaged. Based on reviews, the quality seems good. The small tablets are easy to swallow and have a neutral, slightly salty taste. After a few weeks, I noticed a return to normalcy in my nervous system, increased strength, improved sleep, and more energy.
Read More
8.8
Positive sleep impact
I take 1 tablet every evening before bed and began to sleep better. I’m unsure of the accuracy, but I do see results.
Read More

Frequently Asked Questions

Sleep apnea is a common and potentially serious sleep disorder characterized by irregular breathing patterns during sleep. Individuals with sleep apnea experience episodes of disrupted or paused breathing, which can occur multiple times throughout the night. These interruptions can last a few seconds to several minutes and often lead to fragmented sleep, which may result in excessive daytime sleepiness, irritability, and difficulty concentrating. The condition can be broadly classified into two main types: obstructive sleep apnea (OSA), caused by a blockage of the upper airway, and central sleep apnea (CSA), which occurs when the brain fails to send the proper signals to the muscles that control breathing.

The diagnosis of sleep apnea typically involves a sleep study, either conducted in a sleep clinic or at home using portable monitoring devices. Treatment options vary depending on the severity of the condition but may include lifestyle changes, the use of continuous positive airway pressure (CPAP) machines, oral appliances, or even surgery in some cases. If left untreated, sleep apnea can lead to various health complications, including cardiovascular issues, metabolic disorders, and impaired cognitive function, making it essential to consult a healthcare professional if you suspect you or someone you know may be affected by this disorder.

Folic acid, also known as vitamin B9, is a water-soluble vitamin that plays a crucial role in many bodily functions, particularly in the synthesis of DNA and RNA. It is essential for cell division and is especially important during periods of rapid growth, such as during pregnancy and infancy. The body cannot produce folic acid on its own, which is why it must be obtained from dietary sources or supplements. Commonly found in leafy green vegetables, legumes, seeds, and fortified foods, folic acid is vital for preventing neural tube defects in developing fetuses and is often recommended for women of childbearing age.

In addition to its key role in pregnancy, folic acid contributes to the production of red blood cells and can help reduce the risk of certain types of anemia. Research has also suggested that adequate folic acid levels may be associated with lowered risk of heart disease and other health issues. Most health organizations recommend a daily intake of 400 micrograms for adults, with higher amounts suggested for pregnant women. Incorporating folate-rich foods into your diet, or considering supplementation, can help ensure you meet your folic acid needs.

Based on user reviews, individuals taking the supplement for sleep apnea report varying timelines for noticing results. For some, improvements in sleep quality can be experienced within a few weeks. One user noted a "return to normalcy in my nervous system, increased strength, improved sleep, and more energy" after just a few weeks of use (Read Review). Another reviewer indicated that after starting to take the supplement regularly in the evening, they began to "sleep better," although they were uncertain about the accuracy of their assessment (Read Review).

On the other hand, some users have reported experiencing side effects, which could impact overall benefits. One review emphasized that positive effects such as normalized sleep and improved mood were initially observed, but serious side effects occurred after about 2.5 months of use (Read Review). Given this feedback, it seems that results can vary, but many users may begin to notice positive changes within a few weeks to a couple of months of consistent supplementation.

The research indicates a potential link between dietary folic acid intake and the severity of obstructive sleep apnea (OSA). A study involving 303 adults in Cyprus found that those with higher folic acid consumption tended to experience less severe cases of OSA, suggesting it may offer some protective benefits in managing the condition [3]. However, it's important to note that this study also identified other dietary components that could influence OSA severity, highlighting the need for further research to fully understand how folate interacts with other factors.

While the findings suggest a positive role for folate, the relationship is complex and requires more investigation before definitive conclusions can be made. Thus, while there is some scientific basis for considering folic acid as a beneficial nutrient for those affected by sleep apnea, further exploration is essential to confirm these results and determine the efficacy of supplementation specifically for this condition.

Users have reported a variety of improvements in symptoms related to mood, sleep, and overall well-being after using the supplement. For instance, one user described experiencing a "return to normalcy in my nervous system, increased strength, improved sleep, and more energy" within a few weeks of starting the product (Read Review). Another individual noticed enhanced sleep quality after consistently taking one tablet every evening, expressing a degree of uncertainty about the accuracy of their results but still recognizing positive changes (Read Review).

However, it is important to note that experiences can vary significantly from person to person. One user reported initial positive effects such as normalized sleep, improved mood, and reduced hair loss, but subsequently encountered serious side effects after about 2.5 months of use, including heavy periods attributed to increased estrogen levels (Read Review). Therefore, while many users have reported beneficial outcomes, others have also cautioned about potential side effects, making it advisable for consumers to consult with a healthcare professional before starting supplementation.

Users have reported mixed experiences when combining this supplement with others for managing sleep apnea. One user mentioned successfully incorporating a tablet of folic acid into their routine, which led to improved sleep and a return to a normal state for their nervous system after a few weeks (Read Review). Another reviewer also found that taking a tablet every evening before bed helped enhance sleep quality, although they were uncertain about the reliability of their results (Read Review).

However, caution is warranted, as one user experienced negative side effects after increasing their folic acid dosage, which included sleep disturbances and heavy periods attributed to fluctuations in estrogen levels (Read Review). Users encourage consulting with a healthcare provider before combining supplements, as while some have noticed positive outcomes, others have had adverse reactions affecting their sleep and overall well-being.

Based on user reviews, opinions on the appropriate dose of folic acid for treating sleep apnea vary, but a few common themes emerge. One user reported starting with a single tablet daily and later increased their intake to two tablets per day after experiencing some initial positive effects, such as normalized sleep and improved mood (Read Review). However, this increase led to serious side effects, underscoring the importance of consulting a healthcare provider before adjusting dosages. Conversely, another user found success with a single tablet taken every evening, which resulted in better sleep (Read Review).

Overall, while some users reported benefits from folic acid, they also noted potential side effects, suggesting that the right dose is not one-size-fits-all. A 400 μg dosage has been mentioned as a standard for those new to the supplement, but individual responses can vary significantly, emphasizing the need for personalized medical advice (Read Review).

8.8
Improved sleep quality
I ordered 21st Century folic acid, 400 μg, 250 tablets for the first time. The large packaging arrived undamaged. Based on reviews, the quality seems good. The small tablets are easy to swallow and have a neutral, slightly salty taste. After a few weeks, I noticed a return to normalcy in my nervous system, increased strength, improved sleep, and more energy.
8.8
Positive sleep impact
I take 1 tablet every evening before bed and began to sleep better. I’m unsure of the accuracy, but I do see results.
2.5
Caution advised
Be careful! I had sleep disturbances and read online that folic acid could help with morning migraines. I took one tablet daily for a month and later increased to two. Initially, there were positive effects - normalised sleep, improved mood, and reduced hair loss. However, after 2.5 months, I experienced serious side effects, including heavy periods due to increased estrogen levels. Consult a doctor before use.
We conducted a thorough investigation into how dietary components, particularly folate, relate to the severity of obstructive sleep apnea (OSA) in a group of adults living in Cyprus. Our study included a diverse sample of 303 participants aged over 18, who completed detailed food frequency and physical activity questionnaires, along with undergoing sleep studies to assess OSA severity.

In our analysis, we found that patients with more severe OSA, identified by a higher apnea-hypopnea index (AHI), had significant characteristics such as increased body mass index (BMI) and higher caloric intake. Interestingly, those with moderate to severe OSA reported higher folic acid consumption compared to those with milder forms of the condition.

This suggests that while greater energy intake appears to correlate with more severe OSA, a higher intake of folate may offer some protective benefits. However, it’s essential to note that we did not isolate the effects of folate alone, as other dietary factors were also at play in our findings, making further research necessary to draw stronger conclusions.

Overall, our results point towards the complexity of dietary influences on sleep apnea severity, highlighting folate as a potentially beneficial nutrient alongside other lifestyle factors.

References

  1. Chrysostomou S, Frangopoulos F, Koutras Y, Andreou K, Socratous L, et al. The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study. PLoS One. 2022;17:e0265148. doi:10.1371/journal.pone.0265148
  2. Breaux CW. Obesity Surgery in Children. Obes Surg. 1995;5:279.
  3. Chrysostomou S, Frangopoulos F, Koutras Y, Andreou K, Socratous L, et al. The relation of dietary components with severity of obstructive sleep apnea in Cypriot patients: A randomized, stratified epidemiological study. PLoS One. 2022;17:e0265148. doi:10.1371/journal.pone.0265148
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